LncRNA SPRY4‐IT1 is highly expressed in breast cancer cells, and N‐terminal polypeptide derived from viral macrophage inflammatory protein II (NT21MP) inhibits the biological functions of breast cancer cells through lncRNA SPRY4‐IT1.34 Another study has reported that proliferation is significantly suppressed when SPRY4‐IT1 is knocked down in breast cancer cells by targeting ZNF703.17 However, it is not clear how SPRY4‐IT1 affects the stemness of breast cancer cells. This evidence concerns the gene SPRY4 and breast carcinoma.