MCF‐7, T47D, BT474, MDA‐MB‐436 and JIMT1 cells can be reproduced in long‐term mammosphere cultures, but MDA‐MB‐231 and 468 cells are unable to form long‐term mammosphere cultures.40 In the future, we will continue to investigate if SPRY4‐IT1 promotes stemness, cell proliferation and self‐renewal in other types of breast cancer cells. The gene discussed is SPRY4; the disease is breast cancer.