RPE65 and Leber congenital amaurosis: The most commonly involved genes in this group were CRB1 and GUCY2D, each harboring biallelic defects in 27% (4/15) of probands, followed by RPE65 and RPGRIP1 (MIM *605446), each with pathogenic variants in 13% (2/15) of solved LCA cases (Table 2).