Even though HIF‐2α in EC is vital for vascular integrity, stability and recovery 38, 46, 52, it is also required for the onset and exacerbation of pulmonary hypertension 14, 57, and deletion of lung EC HIF‐2α resulted in ameliorated hypertension phenotypes in mice 14. The gene discussed is EPAS1; the disease is pulmonary arterial hypertension.