CRC-01, the sample with the highest individual mutation load, harbored two mutations that encoded for HLA-I-presented neoantigens: one 8-mer originating from a mutation in the MED25 gene, and one 11-mer from a mutation in U2SURP. A third neoantigen, a 10-mer, was detected in CRC-04, encoded by a mutation in FMO5. No HLA-II-presented neoantigens were identified. The gene discussed is U2SURP; the disease is colorectal carcinoma.