In turn, the pattern of HSPB1 expression was similar to healthy skin in other than above-mentioned hereditary cases of ichthyosis (Jonak et al. 2005), as well as in non-cancerous skin lesions such as actinic keratosis, seborrhoeic keratosis, solar keratosis, and human papillomavirus-induced keratinocyte hyperproliferation (Trautinger et al. 1995a; Gandour-Edwards et al. 1994). The gene discussed is HSPB1; the disease is actinic keratosis.