DISC1 and psychiatric disorder: To address this knowledge gap, we interrogate the developing prefrontal network in a mouse model mimicking both the genetic (mutation of the intracellular hub of developmental processes Disrupted-In-Schizophrenia 1 [DISC1] gene; Brandon and Sawa, 2011) and the environmental (challenge by maternal immune activation [MIA]) background that has been related to mental illness (dual-hit genetic-environmental [GE] mice).