A higher level of chemerin accompanied by more macrophages, and a subsequent increase in inflammation and apoptosis-associated molecules (NLRP3 and Asc) in the brain tissues of offspring of diabetic dams, was observed along with aberrant recognition memory in 8-week-old offspring; these findings indicate that chemerin-macrophage enrichment in brain tissue may participate in the development of brain diseases. This evidence concerns the gene PYCARD and brain disorder.