A similar trend which is shown in Fig. 2 was also observed in the contralateral SVZ in which GET-1 and Ntg slices, there were also few BrdU+Sox2+ positive cell expression and there is no significant difference in the contralateral side of the brain between GET-1 and Ntg mice (figure was not shown), so there were more BrdU+Sox2+ double-labeled cells in the ipsilateral brain slices compared to that in the contralateral side brain of both GET-1 and Ntg mice which indicated that NSC proliferation was induced under ischemic stroke conditions. This evidence concerns the gene OPA1 and ischemic stroke.