PTBP2 and colorectal carcinoma: They also suggested the mechanism underlying the MALAT1 effects, which involved the tumor suppressor gene SFPQ and proto-oncogene PTBP2. Finally, MALAT1 and polypyrimidine tract binding protein 2 (PTBP2) were overexpressed in CRC tissues and associated with the invasion and metastasis of CRC in their study [26].