Since a decrease of CXCR3 + CCR9 + Th cells was found in the circulation of pSS patients and both CCL25 and CXCL10 showed the strongest increased expression in the salivary glands on both mRNA and protein level (Figure 2A and 12, 20), the chemotactic capacity of CXCL10 in combination with CCL25 was investigated. This evidence concerns the gene CXCR3 and peeling skin syndrome.