Since a decrease of CXCR3 + CCR9 + Th cells was found in the circulation of pSS patients and both CCL25 and CXCL10 showed the strongest increased expression in the salivary glands on both mRNA and protein level (Figure 2A and 12, 20), the chemotactic capacity of CXCL10 in combination with CCL25 was investigated. The gene discussed is CCL25; the disease is peeling skin syndrome.