Several chemokines and receptors have been shown to be upregulated in the salivary and lacrimal glands of pSS patients potentially leading to migration of T cells to the glands, including the interferon‐induced chemokines CXCL9, CXCL10, CXCL11 and their receptor CXCR3.4, 5 Recently, CXCR5 + T follicular helper (Tfh) cells and their ligand CXCL13 and CCR9+ ‘Tfh‐like’ cells with their ligand CCL25 have been implicated in disease pathogenesis.6, 7, 8, 9, 10, 11, 12, 13 Both levels of CXCL13 and CCL25 and numbers of CXCR5 + and CCR9 + Th cells are elevated in the salivary glands of pSS patients. The gene discussed is CXCR5; the disease is peeling skin syndrome.