The important role of CXCR3 in pSS is supported by the recent finding that inhibition of CXCR3 impedes development of pSS‐like disease in a sialadenitis mouse model.26 Considering the observation that 40%‐50% of CCR9 + Th cells express CXCR3, it is likely that part of these effects is mediated by blockade of CXCR3 + CCR9 + Th cells. This evidence concerns the gene CCR9 and sialadenitis.