It has been proved that HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and prognosis in a Chinese population.25 Then, the therapeutic value of HOTAIR in ovarian and breast cancers has been demonstrated using tumour specific peptides inhibits HOTAIR activity.26 Silencing of HOTAIR could inhibit the tumour growth and increase chemosensitivity of ovarian tumours in nude mice through regulation of HOXA7.27 In this present study, we found that HOTAIR accelerated the endocrine disorders, ovarian injury and apoptosis of granulosa cells in rat models of PCOS. Here, HOTAIR is linked to endocrine system disorder.