According to the results of RT‐qPCR (Figure 5A‐D), lower expression of miR‐130a and higher expression of IGF1 were identified in the ovarian tissues of the PCOS rat models than the normal rats (P < .05), suggesting that HOTAIR may negatively regulate the expression of miR‐130a and positively regulate the expression of IGF1 in PCOS rat models. Here, HOTAIR is linked to polycystic ovary syndrome.