Accumulating studies showed that circFOXO3 was involved in progression of diseases, such as cardiac senescence21 and non–small‐cell lung cancer.22 Moreover, Burton Yang et al reported circFOXO3 interacted with p21 and CDK2, and retarded cell cycle progression.15 They also detected that circFOXO3 induced tumour apoptosis though enhancing FOXO3 activity.13 However, whether circFOXO3 plays a role in PCa remains unclear. This evidence concerns the gene FOXO3 and neoplasm.