Our data showed that overexpression of SLC25A15 significantly suppressed apoptosis; however, this phenomenon was remarkably abrogated by co‐transfection with sicircFOXO3. By detecting circFOXO3/miR‐29a‐3p/SLC25A15 axis expression in PCa samples, our results also showed a significantly negative correlation between miR‐29a‐3p and circFOXO3 or SLC25A15 in PCa tissues. Here, SLC25A15 is linked to posterior cortical atrophy.