A CD11b+CD11c+T‐bet+ AMB subset appears at the peak of murine gamma herpesvirus 68 (gHV68), lymphocytic choriomeningitis virus (LCMV), murine cytomegalovirus (MCMV), vaccinia, and Friend virus infections.100, 104 These cells are required for production of virus‐specific IgG2a and are critical to clear gHV68 infection.100, 104 A T‐bet+ AMB subset is also critical for the production of protective IgG2a and to control chronic LCMV cl13 infection.99 Thus, in the strong Th1‐biased context of intracellular bacterial and viral infections, AMB appear to be a source of protective antibodies. The gene discussed is ITGAM; the disease is infection.