NFKB1 and neoplasm: Furthermore, Hutti et al70 identified that IKBKE directly phosphorylated an important tumor suppressor, CYLD (cylindromatosis), at the serine 418 site, thus decreasing the deubiquitinase activity of CYLD and decreasing the suppressive functions of TRAF2 and NEMO, which accelerated NF‐κB activity and promoted breast cancer malignant transformation.