IKBKE plays an important role in multiple signaling pathways, including NF‐κB, Akt, STAT (signal transducer and activator of transcription), Hippo and the Wnt/β‐catenin signaling pathways, and participates in the progression of tumors, inflammation‐driven cancer development, tumor microenvironment regulation and so on (Figure 1). This evidence concerns the gene NFKB1 and cancer.