Chen et al43 testified that IKBKE physically interacted with β‐catenin by co‐IP (co‐immunoprecipitation) and that IKBKE phosphorylated β‐catenin, probably at Ser680 and Ser681, to restrain its hyperactivation, thereby promoting colorectal cancer (CRC) cell proliferation. The gene discussed is IKBKE; the disease is colorectal cancer.