Phosphorylated YAP1 induced by LATS, mainly at the serine 127 site, is ubiquitinated by 14‐3‐3 and degrades in the cytoplasm.80 Recently, Lu et al32 discovered that IKBKE promoted the expression of YAP1 and TEAD2 (transcriptional enhancer activation domain 2), which are two important downstream factors of the Hippo pathway in glioma cell lines, thus accelerating the EMT (epithelial‐mesenchymal transition) of cancers. The gene discussed is IKBKE; the disease is central nervous system cancer.