TRAF2 and breast cancer: For breast cancer, IKBKE also promoted the tumorigenesis and progression of tumors by activating the NF‐κB signaling pathway.24, 26, 27, 67, 72 Similarly, Shen et al68 demonstrated that IKBKE directly interacted with and phosphorylated TRAF2 (tumor necrosis factor receptor‐associated factor 2) at serine 11 and then promoted Lys63‐linked TRAF2 ubiquitination to recruit the canonical IKK complex and RIP1, thereby inducing NF‐κB activation and accelerating the malignant transformation of breast cancer cell lines.