Liu et al reported that IKBKE could phosphorylate YB‐1, an oncogenic gene regulator, and then increased its activity to enhance MYC gene transcription.60 Rajurkar et al40 demonstrated that the Gli transcription factor upregulated IKBKE expression at both the mRNA and protein levels, thereby increasing the activity of the NF‐κB pathway to maintain the transformation and survival of Kras‐induced pancreatic cancer cells. Here, IKBKE is linked to familial pancreatic carcinoma.