Moreover, eNOS and inducible nitric oxide synthase (iNOS) play an important role in tumor angiogenesis, vascular tone, and growth (Clemons et al., 2010; Cullis et al., 2006; Fukumura and Jain, 1998; McAdam et al., 2012; Vannini et al., 2015; Ying and Hofseth, 2007). The gene discussed is NOS3; the disease is neoplasm.