Furthermore, though we didn’t find any evidence of association between TAP1 gene polymorphism and the risk of HIV-1 infection, we can’t entirely exclude the role of this immunomodulatory gene in the outcome of HIV-1 infection because of its role in facilitating HLA-I-mediated antigen-presenting pathway resulting CD8+ T cell-mediated immune surveillance against viral infections. Here, CD8A is linked to viral infectious disease.