We didn’t find any evidence of association between TAP1 gene polymorphism and the risk of HIV-1 infection whereas individuals carrying heterozygous (A/G) and homozygous variant (G/G) genotypes of TAP2 gene polymorphism were at 1.39- and 3.38-folds of increased risk of HIV-1 infection and disease outcome, respectively, than those of carrying homozygous wild (A/A) genotype. Here, TAP2 is linked to HIV-1 infection.