Furthermore, key regulators of the miRNA pathway, including DROSHA, DGCR8, AGO1 and AGO2 are frequently overexpressed—rather than downregulated—in HCC (51), and specifically AGO2 overexpression has been shown to promote HCC progression, tumor vascularization (52) and metastasis (53). Here, AGO1 is linked to hepatocellular carcinoma.