MUC5AC and cystic fibrosis: However, these studies are only based on the observation that TMEM16A and mucus/MUC5AC are concomitantly up-regulated during inflammation and/or are carried out in animal models, namely, mice (Huang et al, 2012; Lin et al, 2015; Benedetto et al, 2019), that do not mimic the CF airway disease (Huang et al, 2012; Lin et al, 2015; Benedetto et al, 2019).