Nevertheless, these data appear contradictory to previous reports suggesting that TMEM16A plays a key role in mucus production, namely, in asthma where both TMEM16A and MUC5AC are concomitantly up-regulated by IL-4 or IL-13 induction (Huang et al, 2012; Scudieri et al, 2012; Lin et al, 2015; Kang et al, 2017). This evidence concerns the gene MUC5AC and asthma.