Based on our studies and others who have shown improved neutralizing responses using targeted glycan deletion (Crooks et al., 2017, Dubrovskaya et al., 2017, Ringe et al., 2019, Zhou et al., 2017), presenting Env in ways not seen by HIV during natural infection, such as site-specific deglycosylation to “de-evolve” the glycan shield and thereby altering the elicited responses evolved against it, represents a viable strategy going forward. This evidence concerns the gene ERVW-1 and infection.