Interestingly, in a study by Lukiw et al., four miRNAs (miRNA-9, miRNA-125b, miRNA-146a, and miRNA-155) were upregulated in whole retina samples from AMD patients compared to healthy controls [29]; all of those miRNAs have been shown to specifically bind to the 3′UTR of the CFH gene, thus possibly being major regulators of its expression. This evidence concerns the gene CFH and age-related macular degeneration.