This is consistent with the data on the change in the activity of the abzymes hydrolyzing DNA, myelin basic protein (MBP), MOG (fragment of myelin oligodendrocyte glycoprotein), and histones after immunization of C57BL/6 mice prone to experimental autoimmune encephalomyelitis (EAE) with various antigens [36,48,49]. The gene discussed is MOG; the disease is experimental autoimmune encephalomyelitis.