MMP9 and cancer: Cyclosaplin also demonstrated effective binding affinities towards other cancer-related proteins, such as EGFR (−6.8 kcal/mol) [9], VEGFR2 (−7.8 kcal/mol), PKB (−8.1 kcal/mol), p38 (−8.3 kcal/mol), PTEN-tumor suppressor (−6.3 kcal/mol), and MMP-9 (−7.3 kcal/mol) (Table 4, Figure 3).