When we investigated the use of chIL-2 as an immunoregulator for the defence of chicken Marek’s disease (MD), that is caused by the specific infection and transformation of MDV on chicken immune cells, especially CD4+ T cells, the potential oligomerization of chIL-2 was probed during the purification and administration of chIL-2. This evidence concerns the gene CHI3L2 and Menkes disease.