OPN1SW and metabolic syndrome: In recent years, many studies reported the beneficial properties of BCP against several disorders, in particular cancer, chronic pain and inflammation; among the main ones, recent findings showed chemosensitizing properties for doxorubicin chemotherapy [9], sorafenib [10], and 5-fluorouracil and oxaliplatin [11], neuroprotective effects against cerebral ischemia reperfusion injury [12] and dopaminergic neuron injury [13], cardioprotective features against myocardial infarction [14] and doxorubicin toxicity [15] and, especially, a significant impact in the metabolic syndrome context.