Patients with hypovitaminosis D had higher VZV IgM titers (0.63, SD 0.45), a lower vitamin D supplementation rate (1.5%) and greater spontaneous/brush-evoked pain intensity (6.1, SD 2.1; 4.3, SD 6.8), compared to those in patients with sufficient vitamin D (0.40, SD 0.25; 17.4%; 5.3, SD 1.8; 2.5, SD 8.3) (p = 0.016; 0.005; 0.021; 0.007) (Table 2). This evidence concerns the gene CD40LG and rickets.