Although the causative action of ARID1A has been questioned because siRNA mediated knockdown of BAF250a in OCCC lines (wild type for ARID1A) showed no increase in either pAKT-Thr308 or pAKT-S473 indicating that pAKT in tumor tissues was indirectly regulated by BAF250a expression [58]. The gene discussed is ARID1A; the disease is neoplasm.