PIK3CA and ovarian clear cell cancer: In neoplasms originating from the uterine endometrium, a coexistent ARID1A and PI3K mutations promote epithelial trans-differentiation and collective invasion wherein Wilson et al. observed siARID1A and PIK3CA-H1047R convergence on the NFκB pathway, as previously described in ovarian clear cell carcinoma, and the EMT pathway [77].