ESR1 and ovarian clear cell cancer: A completely different mode of action of ARID1A at the promoter level in ovarian clear cell carcinoma that mechanistically regulate ARID1A mediated tumorigenesis has been presented by Trizzino et al. who showed that ARID1A binds most active promoters and enhancers in ovarian clear cell carcinoma and regulates RNA polymerase II promoter-proximal pausing and exclusively contributes to the transcription of multiple p53 and ESR1 target genes [38].