In concert with the findings from apolipoprotein E (ApoE)−/− or low-density lipoprotein receptor (LDLR)−/− mice inherently prone to the development of atherosclerosis and human atherosclerotic plaques [30], CPB-induced neointima consisted of CD31−αSMA+ cells producing ECM protein collagen IV (Figure 2B,C). This evidence concerns the gene APOE and atherosclerosis.