This finding is in line with earlier studies, where similar serum concentrations of CTX, P1NP, or osteocalcin between MS patients and healthy controls were found, and similar concentrations of cross-linked N terminal telopeptide type 1 collagen (NTX) and bone ALP in newly diagnosed MS patients and healthy controls were found [18,32,65,66,67]. The gene discussed is CYP27A1; the disease is myeloid sarcoma.