Finally, we investigated if a downstream target protein CXCR2 [19], that is known to support tumorigenesis and metastasis of PC, is upregulated by 40 kDa CPE-ΔN and whether it mediates the CPE-ΔN induced increase in proliferation of Panc-1 cells. The gene discussed is CXCR2; the disease is pachyonychia congenita.