As CXCR2 expression was upregulated downstream of CPE-ΔN in the HCC cells [19], we speculated whether CXCR2, a chemokine receptor implicated in driving pancreatic cancer metastasis [17] could be regulated by CPE-ΔN in Panc-1 cells as a mechanism to promote the proliferation and invasion of these cells. Here, CXCR2 is linked to familial pancreatic carcinoma.