Using Panc-1 as an in vitro model of PC, we determined the subcellular distribution of CPE-WT and CPE-ΔN in the PC cells and carried out gain-of-function studies to compare the efficacy of 40 kDa CPE-ΔN versus CPE-WT protein in promoting proliferation and invasion. This evidence concerns the gene CPE and pachyonychia congenita.