In the DEGs of L4h-vs-D4h, the top most represented KEGG categories included TNF signaling pathway, cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, chemokine signaling pathway, influenza A, rheumatoid arthritis, transcriptional misregulation in cancers, malaria, and herpes simplex infection. The gene discussed is TNF; the disease is herpes simplex infectious disease.