Studies of the extract (ethanol/acidic water) of seed oils from cold-pressed fresh grapes, performed by Cecchi et al. [28], demonstrate in vitro inhibitory activity against PTP-1B (protein tyrosine phosphatase 1B enzyme), which is an overexpressed enzyme in type 2 diabetes, showing maximum inhibition values (98%) for Vitis vinifera cv. This evidence concerns the gene PTPN1 and type 2 diabetes mellitus.