In addition, in the placebo group, the cIMT increased after 6 months which also might, in part, explain lower levels of ghrelin as it is known that MetS is a predisposing factor to arterial stiffness, that persistent MetS circumstances can deteriorate the arterial stiffness severity, and that low concentrations of plasma ghrelin are meticulously connected to arterial stiffness [52]. This evidence concerns the gene GHRL and metabolic syndrome.