Kloosterman et al. found among 278 primary colon cancer samples 3 different BRAF gene fusions: AGAP3-BRAF and TRIM24-BRAF (caused by an inversion event) and DLG1-BRAF (deriving from a reciprocal translocation between chromosomes 3 and 7), all of them identified in wild-type BRAF/KRAS/NRAS patients [16]. Here, BRAF is linked to malignant colon neoplasm.