In CRC, NTRK fusions (Table 1a) are associated with female gender, elderly age, right sidedness, lymph node metastatic spread, MSI-H, and RAS and BRAF wild-type status as well as dismal prognosis with median overall survival (OS) of around 15 months in the metastatic setting [27]. The gene discussed is BRAF; the disease is colorectal carcinoma.