This last study also showed increased mitophagy markers in LRRK2-PD, higher levels of PRKN and cleaved PINK only in G2019S-LRRK2 PD and co-localization of TOM20 and LAMP1 in both G2019S- and R1441C-LRRK2 PD [112]. This evidence concerns the gene TOMM20 and Parkinson disease.