An interesting phenomenon worth mentioning is observed in LRRK2-PD cases, where the activities of three lysosomal enzymes (i.e., GCase, alpha-galactosidase and acid sphingomyelinase) were increased, as opposed to decreased or not changed, in GBA-PD and sPD patients, respectively [99]. The gene discussed is LRRK2; the disease is Platelet storage pool disease.