Finally, in PD patients with LRRK2 mutations (LRRK2-PD), fibroblasts carrying different mutations (i.e., R1441G, Y1699C, G2019S) showed no differences in LC3 levels [80], although one study in fibroblasts from G2019S-LRRK2 PD patients showed increased LC3I to LC3II conversion in the majority of patients, suggesting an increased formation of autophagosomes [81]. Here, LRRK2 is linked to Parkinson disease.