Other B-ALL subtypes are characterized by global genetic features, such as hyperdiploidy (>50 chromosomes) or hypodiploidy (<44 chromosomes) [68], or specific transcriptional profiles: PAX5-driven subtypes, DUX4-rearranged, BCR-ABL1-like, or ETV6-RUNX1-like [71,72,73]. The gene discussed is PAX5; the disease is acute lymphoblastic leukemia.