STAT3 activation promotes various protumorigenic effects in stromal cells in HCC, including the production of immunosuppressive molecules from dendritic cells [77], polarization of tumorigenic M2 macrophages to antitumorigenic M1 subtype [78], cancer-associated fibroblast-mediated generation of myeloid-derived suppressor cells, inhibition of T cell proliferation and functions [79] and impairment of natural killer cell-mediated cytotoxicity [80]. The gene discussed is STAT3; the disease is cancer.