Abrogation of STAT3 signaling by the Jak2 inhibitor, AG490, has triggered cell cycle arrest at G0/G1 phase in HCC cells via cyclin D1 downregulation and induced apoptosis by downregulating anti-apoptotic proteins Bcl-xL, survivin and XIAP [68]. The gene discussed is CCND1; the disease is hepatocellular carcinoma.