Moreover, in chronic liver diseases, such as long-term hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, primary biliary cirrhosis (PBC), or alcoholic steatohepatitis (ASH), the level of HMGB1 expression is correlated with the fibrosis stage [22,24,42]. Here, HMGB1 is linked to primary biliary cholangitis.