Other groups have described these changes at length, and they include reduced levels of parvalbumin interneurons(Tewari et al., 2018), decreased expression of KCC2(Pallud et al., 2014), tumor-mediated glutamate release (Buckingham et al., 2011; Ye and Sontheimer, 1999), and reduced glutamate uptake(Yuen et al., 2012). Here, SLC12A5 is linked to neoplasm.