CASP3 and infection: However, compared with the cerebral cortex of EV71-infected mice, we found a lower level of cl-Caspase-3 and dsRNA in the cerebellum of EV71-infected mice on day 1 post-infection (Fig 1E and 1F) and similar observations were obtained on day 3 (S2A and S2B Fig) and day 5 (S2C and S2D Fig) post-infection.