We introduced the following 5 FMH3 associated mutations into our optimized SCN1A expression plasmid: Q1489H and F1499 L were found in families in which FHM was associated with elicited repetitive daily blindness [36] (F1499 L is a recurrent mutation [37]); I1498M and F1661 L were found in patients with pure hemiplegic migraine [38]; M1500 V was detected by screening a cohort of patients with migraine with aura [39]. Here, SCN1A is linked to familial hemiplegic migraine.