NF1 and malignant peripheral nerve sheath tumor: We previously demonstrated that STX3451 induces apoptosis in human NF1-deficient ST88 and S462 malignant peripheral nerve sheath tumour (MPNST) cell lines at very low concentration (300 nM), whilst arresting cell proliferation in an NF1−/−benign plexiform neurofibroma (PNF) [30].