From the analysis results, a higher proportion of the deletions of the zinc finger motif in ZNFs (ZNF283, ZNF724P, ZSCAN20, ZNF606, ZNF169, ZNF430, ZNF20, KDM2B, etc.)were found in samples with IDH mutations (Fig. 6b, c), with similar results in pST2–7 samples (Fig. 4a), demonstrating that zinc fingers might contribute to malignant progression in glioma. Here, KDM2B is linked to central nervous system cancer.