Consistent with the association between IDH status and CIMP in glioma, ST1 was exclusively non-G-CIMP (48/48, 100%), while G-CIMP samples were enriched in ST2 (2/48, 4.2%) and ST3 (6/56, 10.7%) (p < 0.05) (Table 2). Here, IDH1 is linked to central nervous system cancer.