Insulin degludec (degludec) is a basal insulin with an ultra-long duration of action, which has been shown to lead to lower rates of overall confirmed, nocturnal confirmed and severe hypoglycemia compared with insulin glargine 100 units/mL (glargine U100) across different patient populations, including the general diabetes population, elderly patients and patients with type 1 diabetes [33–40]. This evidence concerns the gene INS and Hypoglycemia.