Studies also showed that the over-expression of NUSAP1 stimulated sumoylation of TCF4 via interacting with SUMO E3 ligase Ran-binding protein 2 and hyperactivated Wnt/β-caternin signaling to induce cancer stem cell properties and EMT, and finally promoted the metastasis of cervical cancer [43]. This evidence concerns the gene RANBP2 and cervical cancer.