The Cox’s univariate analysis revealed that comprehensive tumor staging, location, size, nerve invasion, vascular invasion, Borrmann classification, the number of lymph node metastases, the total number of lymph nodes dissected, positive lymph node proportion, lymphocyte count, serum albumin, CEA, CA15–3, CA19–9 and BMI were the influencing factors for the prognosis of gastric cancer after D2 radical resection (P < 0.05, for all). The gene discussed is CEACAM5; the disease is neoplasm.