The fold change analysis between FM CLRDV-infected and FM mock plants (virus-free aphid inoculum) showed that the presence of virus induced an additional systemically down-regulation of almost all their DCLs during the initial stages of virus infection (24 hpi), with the exception of DCL2a. Five days later, however, the levels of all FM DCLs markedly increased, showing almost 60, 10, 47, 17, 28 and 28-fold change variations for DCL1, DCL2a, DCL2b, DCL3a, DCL3b, and DCL4, respectively. The gene discussed is CD302; the disease is viral infectious disease.