PSEN1 and Alzheimer disease: Given that the total amount of GABAB1 protein does not change between wild‐type and APP/PS1 mice, our data suggests that the internalized pool of GABAB receptors was not redirected to subsequent lysosomal degradation in AD, in contrast to the activity‐dependent degradation of GABAB receptors observed in hippocampal and cortical neurons 17, 51.