KCNJ6 and Alzheimer disease: Although no information is yet available about the alterations of these effector ion channels in AD, the decrease of GABAB receptors from the membrane surface of CA1 pyramidal cells, together with the decrease of GIRK2 channels we detected in the same compartments, can produce alteration in GABAB‐mediated GIRK currents 39 and this could involve a change in G protein‐coupling efficiency with effector ion channels 29 or simply that fewer receptors can couple to channels.