ESR1 and neoplasm: Accordingly, we showed that BC patient who develop recurrence earlier (Early and Mid) had primary tumors associated with more aggressive clinical characteristics such as larger tumor, more lymph node metastases, higher pathological grades, higher Stages, and negative ER and PgR, compared to Survivors; however, clinical characteristics of primary tumors with Late recurrence were almost the same as Survivors (Tables 1–3).