Interestingly, there was no statistically significant difference in clinical features between Survivors and Late recurrence group in TCGA, whereas, Late was significantly associated with lymph node metastasis (p = 0.000029), positive ER (p = 0.014), high frequency of the HR + HER2− group (p = 0.0017), and treatment with adjuvant endocrine therapy (p = 0.014), compared to Survivors in distant metastasis analysis of METABRIC (Table 2). The gene discussed is ESR1; the disease is metastatic malignant neoplasm in the lymph nodes.