AKT1 and lung adenocarcinoma: Since activation of Akt is considered to be responsible for tumor aggressiveness30, using publicly available database (KM plotter; mplot.com/analysis/index.php?p = service&cancer = lung), survival curves were analysed with reference to Akt expression (Fig. 2A) in lung adenocarcinoma, which indicated lower patient survival rate with higher Akt expression (analyses criteria explained in Material and Methods).