NFKB1 and colorectal carcinoma: Based on these results, we hypothesized that the aberrant activation of NF-κB induced by 5-Fu was one of the major causes leading to CRC chemoresistance and that aspirin enhanced the sensitivity of chemoresistant CRC cells to 5-Fu, which was possibly achieved through abolishing the 5-Fu-induced abnormal activation of NF-κB.